Yuav luag txhua yam roj ntses, vitamin-E, lossis cov tshuaj ntxiv, thiab koj yuav tuav tau ib lub tshuaj ntsiav gelatin mos mos - ib lub tshuaj ntsiav mos mos. Cov tshuaj ntsiav uas kaw, ib daim no tau dhau los ua hom tseem ceeb rau cov kua thiab cov kua ib nrab vim tias lawv yooj yim nqos, pom tseeb tias muaj kev cuam tshuam, thiab zoo heev rau kev tiv thaiv cov roj rhiab heev ntawm cov pa oxygen. Tab sis lub tshuaj ntsiav uas koj noj yog cov mis tshuaj uas raug cai, thiab gelatin yog lub hnub qub ntawm lub plhaub.
Phau ntawv qhia no piav qhia txog yuav ua li cas cov plhaub softgel raug tsim, vim li cas gelatin tseem siv dav, thiab cov khoom gelatin twg yuav tsum tau soj ntsuam kom txhawb nqa kev tsim cov ribbon txhim khu kev qha, kev sib khi, kev ziab, thiab kev tso tawm. Nws kuj tseem tshuaj xyuas seb cov khoom sib xyaw ntawm lub plhaub, kev sib raug zoo ntawm cov khoom sau, kev teeb tsa encapsulation, thiab cov xwm txheej khaws cia tuaj yeem cuam tshuam li cas rau kev ncaj ncees ntawm cov xov, kev xau, kev tawg, kev nplaum, kev yaj, thiab kev ua haujlwm ntawm lub sijhawm khaws cia.
Lub Tshuaj Gelatin Mos Yog Dab Tsi?
Ib daim softel yog ib daim ntawv qhia tshuaj uas muaj cov kua, cov kua suspension, paste, lossis semisolid fill nyob hauv ib lub plhaub gelatin yas. Tsis zoo li ob daim capsule tawv (saib peb phau ntawv qhia rautshuaj ntsiav gelatin tawv), cov gelatin ribbons thiab cov khoom sau tau muab coj los ua ke thaum lub sijhawm encapsulation thiab kaw los ntawm cov txheej txheem rotary-die. Cov tshuaj ntsiav tshiab uas tsim feem ntau yuav raug ziab thawj zaug ua raws li kev ziab ntxiv kom txog thaum lub plhaub noo noo, qhov nyuaj, kev sib txuas, thiab kev ruaj khov ntawm qhov ntev tau raug ncav cuag. Softgels tuaj yeem tsim tawm hauv oval, oblong, puag ncig, raj, lossis cov duab tshwj xeeb thiab tuaj yeem pab zais qhov saj, tsw, thiab qhov tsos ntawm cov khoom sau.
Lub plhaub tsis yog gelatin ntshiab. Nws yog ib daim zaj duab xis uas muaj gelatin, ib yam khoom ua kom yas (feem ntau yog glycerin lossis sorbitol), thiab dej sib xyaw ua ke, nrog rau xim, opacifier, lossis cov tshuaj enteric xaiv tau. Cov gelatin muab lub hauv paus tseem ceeb rau kev tsim zaj duab xis; cov khoom ua kom yas ua rau zaj duab xis yoog tau es tsis txhob tawg yooj yim.
Kev ua kom tau qhov sib npaug zoo yog qhov kev txawj ntse tseem ceeb ntawm kev tsim cov softgel. Siv cov plasticizer tsawg dhau thiab lub plhaub yuav tawg; siv ntau dhau thiab nws yuav nplaum, lo rau ntawm cov pwm, thiab quaj roj. Qib gelatin teeb tsa lub qab nthab ntawm seb zaj duab xis yuav ruaj khov npaum li cas, yog vim li cas cov mis ntawm lub plhaub thiab cov lus qhia gelatin tau tsim ua ke, tsis yog sib cais.
Vim li cas Gelatin - thiab Dab Tsi Lub Plhaub Xav Tau
Gelatin tseem siv dav hauv kev tsim cov softgel vim nws ua ke muaj peev xwm tsim zaj duab xis, thermoreversible gelation, lub zog kho tshuab, thiab cov txheej txheem rotary-die uas tau tsim tsa.
- Kev tsim cov zaj duab xis thiab kev ywj pheej. Thaum ua kom yas zoo, gelatin tuaj yeem tsim cov ribbons txuas ntxiv mus nrog lub zog thiab kev ywj pheej uas xav tau rau kev puab, kev sau, thiab kev kaw.
- Kev ua cov khoom siv thermoreversible. Gelatin tuaj yeem npaj tau ua cov gel mass sov, ntws tau thiab tom qab ntawd teeb tsa thaum cov ribbons txias, txhawb nqa kev sib txuas ntawm rotary-die encapsulation.
- Kev tsim cov leeg. Kev rheology gelatin tsim nyog, ua ke nrog kev tswj qhov tuab ntawm daim kab xev, qhov kub ntawm qhov wedge, lub zog ntawm lub pwm, thiab qhov ceev ntawm lub tshuab, txhawb nqa kev tsim cov leeg capsule muaj zog thiab sib xws.
- Kev Pab Txhawb Kev Thaiv. Lub plhaub txuas ntxiv thiab kaw kom zoo tuaj yeem txo qhov kev raug ncaj qha ntawm qhov sau rau sab nraud. Txawm li cas los xij, kev tiv thaiv oxidation kuj nyob ntawm qhov sib txuas, cov khoom sau, qhov chaw taub hau, cov tshuaj antioxidants, cov ntaub ntawv ntim khoom, thiab cov xwm txheej khaws cia.
- Kev tawg ua tej daim me me thiab tso cov khoom sau. Cov plhaub gelatin txheem yog tsim los kom tawg ua tej daim me me thiab tso cov khoom sau rau hauv qab cov xwm txheej sim tsim nyog. Txhua qhov kev txhim kho hauv kev siv tau ntawm cov khoom siv lipophilic feem ntau yog cuam tshuam nrog cov qauv sau tiav thiab kev tsim cov tshuaj ntau npaum li cas es tsis yog rau lub plhaub gelatin nkaus xwb.
Cov khoom no ua rau gelatin haum rau ntau yam tshuaj thiab nutraceutical softgels. Kev ua tau zoo nyob rau hauv qhov kub siab lossis av noo, lossis nyob rau hauv kev sib cuag nrog cov khoom xyaw reactive fill, txawm li cas los xij yuav tsum tau lees paub los ntawm kev sib raug zoo thiab kev ruaj khov kev tshawb fawb.
Rau lub plhaub kom ua haujlwm,tshuaj gelatinsiv yuav tsum ua tau raws li cov lus qhia nruj:
- Lub zog gel. Lub zog gel pab txhawb rau lub zog kho tshuab thiab kev teeb tsa tus cwj pwm ntawm cov yeeb yaj kiab gelatin.
- Qhov Viscosity. Qhov viscosity cuam tshuam rau kev npaj gel-mass, kev tsim ribbon, kev pumping, kev nthuav dav, thiab kev loj hlob ntawm cov xov.
- pH. pH tuaj yeem cuam tshuam rau kev ua thiab kev sib haum xeeb nrog lwm cov khoom siv plhaub lossis cov khoom sau.
- Kev zoo ntawm cov kab mob me me thiab tshuaj lom neeg. Cov lus qhia tshwj xeeb uas siv tau yuav suav nrog cov kev txwv ntawm cov kab mob me me, cov khoom tsis huv lossis cov hlau hnyav, sulfur dioxide, cov yam ntxwv ntsig txog peroxide, thiab lwm yam kev ntsuam xyuas uas xav tau los ntawm cov tshuaj pharmacopoeia, cov lus qhia tshwj xeeb ntawm cov neeg siv khoom, lossis kev lag luam uas xav tau.
- Xim thiab qhov meej. Qhov zoo ntawm cov khoom siv raw, kev ntxuav, keeb kwm thermal, thiab qhov muaj cov khoom ntxiv rau hauv lub plhaub cuam tshuam rau qhov zoo li ntawm lub tshuaj ntsiav tiav. Qhov loj ntawm cov khoom me me tuaj yeem cuam tshuam rau kev sib kis ntawm gelatin thiab kev npaj gel-mass tab sis tsis txiav txim siab qhov meej ntawm lub plhaub.
- Kev ruaj khov ntawm kev yaj thiab kev pheej hmoo ntawm kev sib txuas. Qhov chaw ntawm gelatin, cov yam ntxwv ntawm molecular, cov khoom xyaw reactive fill, qhov kub thiab txias cia, av noo, thiab kev ntim khoom tuaj yeem cuam tshuam rau kev sib txuas thiab kev ua haujlwm ntawm kev sau-tso tawm thaum lub sijhawm khaws cia. Yog tias qhov kev sau muaj kev pheej hmoo ntawm kev sib txuas paub, yuav tsum xav txog qib gelatin thiab txoj kev yaj uas tau lees paub.
Yuav Ua Li Cas Softgel Formulation Ua Haujlwm Hauv Kev Xyaum
Ib qho qauv ntawm lub plhaub softgel feem ntau yog kwv yees li:
- Gelatin: 30–40% ntawm qhov hnyav ntawm lub plhaub - lub hauv paus ntawm cov qauv.
- Cov tshuaj ua kom yas (glycerin/sorbitol): 20–30 % — tiv thaiv kev tawg thiab tswj cov qauv.
- Dej: 30–40% — tsav cov gelation thaum lub sijhawm casting; feem ntau raug tshem tawm hauv qhov av qhuav.
Raws li txoj cai yooj yim, kev txo qib gelatin lossis tsa lub plasticizer ua rau lub plhaub mos dua, ywj dua; kev tsa gelatin lossis txo lub plasticizer ua rau nws ruaj khov thiab tawg yooj yim dua. Lub ntsiab lus "yog" nyob ntawm cov roj ntawm cov khoom sau, qhov loj ntawm lub tshuaj ntsiav, thiab yuav ua li cas cov khoom yuav raug tuav thiab khaws cia. Kev khiav me me ntawm qhov sau tiag tiag yog tib txoj hauv kev txhim khu kev qha los xauv qhov sib piv ua ntej kev khiav lag luam.
Cov khoom sau nws tus kheej tuaj yeem yog roj, cov hmoov uas muaj nyob hauv roj, lossis cov nplaum. Cov khoom kos duab no yog sib phim lub plhaub thiab cov khoom sau kom tsis muaj qhov txav mus rau lwm qhov thiab lub tshuaj ntsiav tseem kaw thaum ziab thiab khaws cia. Qhov no yog qhov uas tus neeg muag khoom gelatin uas muaj kev paub dhau los khwv tau nws qhov kev khaws cia - kev sib koom ua ke tsim cov qib thiab cov khoom yas rau koj cov khoom siv tshwj xeeb.
Yuav Ua Li Cas Softgel Thiaj Ua Tau
Hauv kev tsim cov pwm rotary-die, ob daim gelatin ribbons txuas ntxiv mus raug tsim thiab coj ntawm ib khub pwm sib phim. Qhov sau yog ntsuas los ntawm cov wedge txhaj tshuaj thaum cov pwm ua duab, sau, txiav, thiab kaw txhua lub capsule. Cov zis ntau lawm nyob ntawm qhov loj ntawm lub capsule, cov cuab yeej, cov qauv tshuab, cov khoom sau, cov tuab ntawm ribbon, cov kev xav tau ntawm cov seam, thiab qhov ceev ua haujlwm; nws yuav tsum tsis txhob piav qhia siv ib qho nqi tso zis thoob ntiaj teb.
Feem ntau cov tshuaj ntsiav uas tshiab tsim yuav raug ziab thawj zaug tom qab ntawd yuav raug tswj kom qhuav zaum ob. Kev ziab yuav txuas ntxiv mus txog thaum lub plhaub dej noo, qhov tawv, qhov sib txuas, thiab qhov ruaj khov. Txawm hais tias cov plhaub tiav lawm feem ntau khaws cov dej tshuav tsawg, qhov kawg ziab yuav tsum tau teeb tsa rau cov qauv plhaub tshwj xeeb, kev sau, cov qauv tshuaj ntsiav, kev ntim khoom, thiab kev ruaj khov.
Cov tshuaj Softgels piv rau lwm cov tshuaj
| Hom ntawv | Lub hauv paus plhaub | Zoo tshaj plaws rau | Kev Saib Xyuas |
|---|---|---|---|
| Cov tshuaj mos mos | Gelatin (+ yas ua kom zoo dua) | Cov tshuaj ua kua / roj, ib zaug ib hnub | Xav tau kev tswj hwm gelatin viscosity & ziab |
| Tshuaj ntsiav tawv | Gelatin (ob daim) | Hmoov thiab granules | Tsis yog rau cov kua dej ntws dawb |
| Tshuaj ntsiav | Tsis muaj (compressed) | Cov khoom khov kho siab | Tsis zoo rau cov roj; qeeb qeeb yaj |
| Cov tshuaj softgel uas tsis yog gelatin | Cov cellulose cog | Kev thov zaub mov tsis muaj nqaij | Kev thaiv thiab kev kaw sib txawv; xav tau kev kho dua tshiab |
Cov Lus Nug Feem Ntau
Puas ua tau cov softgels yam tsis muaj gelatin?
Yog — HPMC (cov nroj tsuag cellulose) softgels muaj rau kev tso zaub rau cov neeg tsis noj nqaij, tab sis lawv kaw thiab thaiv txawv, yog li cov qauv yuav tsum tau tsim dua tshiab es tsis txhob hloov pauv. Gelatin tseem yog lub neej ntawd rau kev ua tau zoo thiab tus nqi. Gelken tuaj yeem muab ob qho tib si gelatin thiab HPMC-tshaj qib thiab yuav qhia txog kev pauv pauv rau koj lub khw, yog li kev xaiv yog kev siv tshuab, tsis yog tsuas yog daim ntawv lo.
Dab tsi ua rau softgel xau lossis brittleness?
Feem ntau qhov tsis sib xws ntawm qib viscosity/plasticizer ntawm lub plhaub gelatin thiab qhov sau, lossis qhov dej noo tsis raug thaum ziab. Cov qauv gelatin nruj thiab cov qauv ziab uas tau lees paub daws teeb meem feem ntau. Kev kuaj xyuas cov dej noo ntawm lub plhaub thaum lub sijhawm ziab kom ntes tau ua ntej nws dhau los ua khib nyiab, yog vim li cas qhov viscosity ntawm gelatin uas tswj tau tseem ceeb npaum li daim ntawv qhia ua zaub mov.
Puas yog gelatin cuam tshuam rau cov khoom xyaw nquag?
Gelatin feem ntau tsis muaj zog thiab yaj hauv plab, yog li nws tsis tshua muaj kev sib cuag nrog cov khoom sau. Rau cov tshuaj uas ua rau rhiab heev rau cov kua qaub, lub plhaub enteric lossis Modified Release tuaj yeem tsim rau saum lub hauv paus gelatin. Rau feem ntau cov roj nutraceutical, cov tshuaj gelatin txheem yog sib xws tag nrho; tsuas yog ob peb yam tshuaj uas ua rau muaj kev cuam tshuam lossis cov kua qaub ntau heev xav tau lub plhaub tshwj xeeb.
Cov softgels khaws cia tau ntev npaum li cas, thiab yuav tsum khaws cia li cas?
Yog tias lub plhaub muaj dej noo zoo (feem ntau yog 5–10% tom qab ziab) thiab qib gelatin ruaj khov, cov softgels feem ntau muaj lub sijhawm khaws cia 2–3 xyoos. Khaws cia rau hauv qab ~ 25 ° C thiab deb ntawm qhov av noo siab kom tiv thaiv lub plhaub mos lossis lo, thiab zam kev tshav ntuj ntev, uas tuaj yeem ua rau oxidation ntawm qhov ntim khoom sai dua. Gelken tuaj yeem qhia txog cov qauv plhaub thiab kev teeb tsa ntim khoom uas ua tau raws li koj lub sijhawm khaws cia hauv thaj chaw huab cua ntawm kev lag luam.
Xaus lus
Cov tshuaj ntsiav gelatin mos yog qhov ua tiav ntawm kev tsim cov mis: lub plhaub gelatin uas tau tsim tshwj xeeb uas tiv thaiv, muab tshuaj, thiab xa cov kua dej kom huv si. Kev ua kom lawv raug pib nrog gelatin - nws lub zog Bloom, viscosity, thiab kev dawb huv teeb tsa seb koj lub tshuaj ntsiav kaw, mus ncig, thiab ua haujlwm.
Yog tias koj tab tom tsim lossis scaling ib lub softgel,tham nrog peb pab neeg thovtxoggelatin tshuaj qibphim rau koj qhov sau thiab tuag. Thiab rau daim duab dav dua, peb cov lus qhia rautshuaj ntsiav gelatin tawvthiablub zog ntawm gelatin tawg pajUa kom tiav qhov uas txhua tus neeg yuav tshuaj ntsiav yuav tsum paub. Kev tau txais qib plhaub kom raug thaum tsim qauv pheej yig dua li kho qhov xau thiab rov qab tom qab tso tawm.
